Цукровий діабет, як фактор нейродегенарації Альцгеймерівського типу (огляд літератури)

Автор(и)

  • I. R. Tymofiychuk
  • V. V. Gordienko
  • V. I. Shvets

DOI:

https://doi.org/10.24061/165114

Ключові слова:

хвороба Альцгеймера, цукровий діабет, нейродегенерація

Анотація

Хвороба Альцгеймера (ХА) представляє собою тяжке нейродегенеративне захворювання, яке призводить до втрати пам´яті, вираженим когнітивним розладам і неминучої смерті. Кінцевим результатом розвитку патологічного процесу є масова загибель нейронів у специфічних структурах мозку, які пов’язані зі зберіганням і переробкою інформації. Показник розповсюдження ХА зростає з віком. Цукровий діабет (ЦД) вважається процесом, який може бути аналогічним до прискореного старіння - при цьому захворюванні зростає схильність до дегенеративних станів. В останні роки отримано дані, що діабет може стати причиною прискореного старіння мозку.

Посилання

Borovkova SO, Iftodii AH. Pytannia patohenezu diabetychnykh anhiopatii [The question of the pathogenesis of diabetic angiopathy]. Bukovyns'kyi medychnyi visnyk. 2006;10(2):132-36. (in Ukrainian).

Brodiak IV, Sybirna NO. Osoblyvosti metabolizmu L-arhininu v leikotsytakh krovi za umov eksperymental'noho tsukrovoho diabetu [Features of metabolism of L-arginine in blood leukocytes under experimental diabetes mellitus]. Fiziolohichnyi zhurnal. 2008;54(1):63-8. (in Ukrainian).

Zak KP, Popova VV. Tsitokiny i sakharnyy diabet 1-go tipa u cheloveka (obzor s vklyucheniem sobstvennykh dannykh) [Cytokines and type 1 diabetes mellitus person (review with the inclusion of their own data)]. Ukrains'kyi medychnyi chasopys. 2006;І/II(1):78-9. (in Russian).

Mahura IS. Mozkova ishemiia-hipoksiia ta biofizychni mekhanizmy neirodeheneratyvnykh i neiroprotektornykh vplyviv [Cerebral ischemia is hypoxia and biophysical mechanisms of neurodegenerative and neuroprotective effects]. Fiziolohichnyi zhurnal. 2003;49(2):7-11. (in Ukrainian).

Orlovskiy MA. Aktivatsiya ekspressii indutsiruemoy sintazy oksida azota v gippokampe pri razvitii eksperimental'nogo sakharnogo diabeta [Activation of expression of inducible nitric oxide synthase in the hippocampus in the development of experimental diabetes mellitus]. Ukrainskiy nevrologicheskiy zhurnal. 2007;4:88-2. (in Russian).

Pinchuk IYa. Faktor zadovolenosti rodychiv patsiienta vzaiemodiieiu, yak pidkhid do zabezpechennia yakosti psykhiatrychnoi dopomohy [Factor of satisfaction of the relatives of the patient interaction as an approach to ensuring the quality of psychiatric care]. Visnyk psykhiatrii ta psykhofarmakoterapii. 2009;1:32-4. (in Ukrainian).

Chaikovs'ka VV, Verzhykovs'ka NV, Khadzhynova NA. Stan orhanizatsii heriatrychnoi dopomohy naselenniu litn'oho viku v Ukraini [The state of the organization of geriatric care to the elderly inUkraine]. Problemy stareniya i dolgoletiya. 2006;6:358-66. (in Ukrainian).

Shestakova SA, Stepanov RP, Grigorenko GA. Antioksidantnaya zashchita i strukturnye izmeneniya v golovnom mozge u krys pri eksperimental'nom sakharnom diabete [Antioxidant protection and structural changes in the brain in rats with experimental diabetes mellitus]. Problemy endokrinologii. 2006;52(5):37-7. (in Russian).

Arushanyan EB, Beyer EV. Gippokamp i narusheniya poznavatel'noy deyatel'nosti [Hippocampus and cognitive dysfunction]. Zhurnal nevrologii i psikhiatrii. 2007;7:72-7. (in Russian).

Baranov VS, Baranova EV. Geneticheskie aspekty stareniya [Genetic aspects of aging]. Uspekhi gerontologii. 2007;20:26-4. (in Russian).

Vast'yanov RS, Oleynik AA. Neyrotropnye effekty tsitokinov i faktorov rosta [Neurotropic effects of cytokines and growth factors]. Uspekhi fiziologicheskikh nauk. 2007;38(1):39-4. (in Russian).

Islamov RR, Rizvanov AA, Guseva DS, Kiyasov AP. Gennaya i kletochnaya terapiya neyrodegenerativnykh zabolevaniy [Gene and cell therapy of neurodegenerative diseases]. Kletochnaya transplantologiya i tkanevaya inzheneriya. 2007;11(3):29-7. (in Russian).

Mukhamed'yarov MA, Zefirov AL. Vliyanie beta-amiloidnogo peptida na funktsii vozbudimykh tkaney: fiziologicheskie i patologicheskie aspekty [Influence of beta-amyloid peptide on the functions of excitable tissues: physiological and pathological aspects]. Uspekhi fiziologicheskikh nauk. 2013;44(1):55-1. (in Russian).

Mukhamed'yarov MA, Zefirov AL. Mekhanizmy kratkovremennoy formy sinapticheskoy plastichnosti [Mechanisms of short-term form of synaptic plasticity]. Rossiyskiy fiziologicheskiy zhurnal im. I.M. Sechenova. 2004;90(8):1041-59. (in Russian).

Naumenko VG. Patogeneticheskaya terapiya oslozhneniy sakharnogo diabeta [Pathogenetic therapy of complications of diabetes mellitus]. Mezhdunarodnyy endokrinologicheskiy zhurnal. 2006;1:71-6. (in Russian).

Popova MS, Stepanichev MYu. Induktsiya kletochnogo tsikla, amiloid-beta i svobodnye radikaly v mekhanizme razvitiya svobodno-radikal'nykh protsessov v mozge [Induction of the cell cycle, amyloid-beta and free radicals in the mechanism of development of free radical processes in the brain]. Neyrokhimiya. 2008;25(3):1-9. (in Russian).

Povitsenko AF, Abramov VV, Kozlov VA. Tsitokiny i faktory neyroendokrinnoy regulyatsii [Cytokines and factors of neuroendocrine regulation]. Uspekhi fiziologicheskikh nauk. 2007;38(3):40-6. (in Russian).

Bachurin SO, Grigor'ev VV, Ivanova TA. Rol' glutamatnykh retseptorov v razvitii i lechenii bolezni Al'tsgeymera [The role of glutamate receptors in the development and treatment of Alzheimer's disease]. Symposium materials [Current state of research, diagnosis and therapy of neurodegenerative diseases (Alzheimer's, Parkinson's, etc.)]. 17-18 November 2005, Moskow. Moskow; 2005. 99-104 p. (in Russian).

Garibova TL, Voronina TA, Litvinova SA. Effekt nooglyutila na povedenie i pamyat' myshey linii SAM (Senescence-accelerated mouse) s geneticheski determinirovannym uskorennym stareniem [The effect of nooglutil on the behavior and memory of SAM mice (Senescence-accelerated mouse) with genetically determined accelerated aging]. Eksperimental'naya i klinicheskaya farmakologiya. 2007;70(4):3-6. (in Russian).

Crouch PJ, Harding SM, White AR. Mechanism of A beta mediated neurodegeneretion in Alzheimers disease. Internat J Biochemistry @ Cell Biol. 2008;40(2):181-98.

Conde JR, Streit WJ. Microglia in the aging brain. Neuropathol Exp Neurol. 2006;65:199-3.

Devi L, Prabhu BM, Galati DF. Accumulation of amyloid precursor protein in the mitochondrial import channels of human Alzheimer's disease brain is associated with mitochondrial dysfunction. J Neurosci. 2006;26:905.

Gouras GK, Tampellini D, Takahashi RH, Capetillo-Zarate E. Intraneuronal beta-amyloid accumulation and synapse pathology in Alzheimer's disease. Acta Neuropathol. 2010;119:523-41.

Fjell AM, Walhovd KB. Structural brain changes in aging: courses, causes and cognitive consequences. Rev Neurosci. 2010;21(3):187-21.

Foster Е. Calcium homeostasis and modulation of synaptic plasticity in the aged brain. Aging Cell. 2007;7:319-25.

Moreira RO, Campos SC, Soldera AL. Type 2 Diabetes Mellitus and Alzheimer's Disease: from physiopathology to treatment implications. Diabetes Metab Res Rev. 2013;10:1002.

Mora F, Segovia G, ArcodelA. Aging, plasticity and environmental enrichment: structural changes and neurotransmitter dynamics in several areas of the brain. Brain Res Rev. 2007;55:78-8.

Nocolls MR. The clinical and biological relationship between Type II diabetes mellitus and Alzheimer's disease. Curr Alzheimer Res. 2004;1:47-4.

Pari L, Murugan P. Influence of tetrahydrocurcumin on tail tendon collagen contents and its properties in rats with streptozotocin- nicotinamide-induced type 2 diabetes. Fundam Clin Pharmacol. 2007;21:665-71.

Priller C, Bauer T, Mitteregger G. Synapse formation and function is modulated by the amyloid precursor protein. J Neurosci. 2006;26:7212-221.

Predrag Š, Douglas NI. Insulin and insulin-like growth factor prevent brain atrophy and cognitive impairment in diabetic rats. Indian J Endocrinol Metab. 2012;16:601-10.

Robinson LE, Buchholz AC, Mazurak VC. Inflammation, obesity, and fatty acid metabolism: influence of n-3 polyunsaturated fatty acids on factors contributing to metabolic syndrome. Appl Physiol Nutr Metab. 2007;32:1008-24.

Rodríguez-Mañas L, El-Assar M, Vallejo S. Endothelial dysfunction in aged humans is related with oxidative stress and vascular inflammation. Aging Cell. 2009;8:226-38.

Reddy PH, Manczak M, Mao P. Amyloid-beta and mitochondria in aging and Alzheimer's disease: implications for synaptic damage and cognitive decline. J Alzheimers Dis. 2010;20:499-12.

Shi J, Zhang S, Tang M. Mutation Screening and Association Study of the Neprilysin Gene in Sporadic Alzheimer’s Disease in Chinese Persons. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 2005;60:301-6.

Smith DG, Cappai R, Barnham KJ. The redox chemistry of the Alzheimer’s disease amyloid beta peptide. Biochim Biophys Acta. 2007;1768:1976-990.

Rutten BP, Korr H, Steinbusch HW, Schmitz CH. The aging brain: less neurons could be better. Mechanisms of Ageing and Development. 2003;124:349-55.

##submission.downloads##

Опубліковано

2021-12-09

Номер

Розділ

НАУКОВІ ОГЛЯДИ