DOI: https://doi.org/10.24061/165087

Пероксидне окиснення ліпідів у хворих на туберкульоз легень

V. I. Slyvka

Анотація


Одним з універсальних механізмів ушкодження клітинних мембран є пероксидне окиснення ліпідів (ПОЛ), надмірній активації якого в нормі запобігають фактори системи антиоксидантного захисту. До мембранозв’язаних ферментів, що беруть участь в утворенні продуктів ПОЛ, належать ліпоокси- та циклооксигенази. Процеси ліпопероксидації змінюють структуру та фосфоліпідний склад мембран клітин, що негативно впливає на клітинну імунну відповідь внаслідок ушкодження механізмів передачі інформації від позаклітинних регуляторів до внутрішньоклітинних ефекторних систем.


Ключові слова


туберкульоз легень; протитуберкульозні препарати; пероксидне окиснення ліпідів; антиоксидантний захист

Повний текст:

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Посилання


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Copyright (c) 2019 V. I. Slyvka

Технічний редактор журналу, к.мед.н. М. Степанченко, 2015-2019