DOI: https://doi.org/10.24061/165114

Цукровий діабет, як фактор нейродегенарації Альцгеймерівського типу (огляд літератури)

I. R. Tymofiychuk, V. V. Gordienko, V. I. Shvets

Анотація


Хвороба Альцгеймера (ХА) представляє собою тяжке нейродегенеративне захворювання, яке призводить до втрати пам´яті, вираженим когнітивним розладам і неминучої смерті. Кінцевим результатом розвитку патологічного процесу є масова загибель нейронів у специфічних структурах мозку, які пов’язані зі зберіганням і переробкою інформації. Показник розповсюдження ХА зростає з віком. Цукровий діабет (ЦД) вважається процесом, який може бути аналогічним до прискореного старіння - при цьому захворюванні зростає схильність до дегенеративних станів. В останні роки отримано дані, що діабет може стати причиною прискореного старіння мозку.


Ключові слова


хвороба Альцгеймера; цукровий діабет; нейродегенерація

Повний текст:

PDF

Посилання


Borovkova SO, Iftodii AH. Pytannia patohenezu diabetychnykh anhiopatii [The question of the pathogenesis of diabetic angiopathy]. Bukovyns'kyi medychnyi visnyk. 2006;10(2):132-36. (in Ukrainian).

Brodiak IV, Sybirna NO. Osoblyvosti metabolizmu L-arhininu v leikotsytakh krovi za umov eksperymental'noho tsukrovoho diabetu [Features of metabolism of L-arginine in blood leukocytes under experimental diabetes mellitus]. Fiziolohichnyi zhurnal. 2008;54(1):63-8. (in Ukrainian).

Zak KP, Popova VV. Tsitokiny i sakharnyy diabet 1-go tipa u cheloveka (obzor s vklyucheniem sobstvennykh dannykh) [Cytokines and type 1 diabetes mellitus person (review with the inclusion of their own data)]. Ukrains'kyi medychnyi chasopys. 2006;І/II(1):78-9. (in Russian).

Mahura IS. Mozkova ishemiia-hipoksiia ta biofizychni mekhanizmy neirodeheneratyvnykh i neiroprotektornykh vplyviv [Cerebral ischemia is hypoxia and biophysical mechanisms of neurodegenerative and neuroprotective effects]. Fiziolohichnyi zhurnal. 2003;49(2):7-11. (in Ukrainian).

Orlovskiy MA. Aktivatsiya ekspressii indutsiruemoy sintazy oksida azota v gippokampe pri razvitii eksperimental'nogo sakharnogo diabeta [Activation of expression of inducible nitric oxide synthase in the hippocampus in the development of experimental diabetes mellitus]. Ukrainskiy nevrologicheskiy zhurnal. 2007;4:88-2. (in Russian).

Pinchuk IYa. Faktor zadovolenosti rodychiv patsiienta vzaiemodiieiu, yak pidkhid do zabezpechennia yakosti psykhiatrychnoi dopomohy [Factor of satisfaction of the relatives of the patient interaction as an approach to ensuring the quality of psychiatric care]. Visnyk psykhiatrii ta psykhofarmakoterapii. 2009;1:32-4. (in Ukrainian).

Chaikovs'ka VV, Verzhykovs'ka NV, Khadzhynova NA. Stan orhanizatsii heriatrychnoi dopomohy naselenniu litn'oho viku v Ukraini [The state of the organization of geriatric care to the elderly inUkraine]. Problemy stareniya i dolgoletiya. 2006;6:358-66. (in Ukrainian).

Shestakova SA, Stepanov RP, Grigorenko GA. Antioksidantnaya zashchita i strukturnye izmeneniya v golovnom mozge u krys pri eksperimental'nom sakharnom diabete [Antioxidant protection and structural changes in the brain in rats with experimental diabetes mellitus]. Problemy endokrinologii. 2006;52(5):37-7. (in Russian).

Arushanyan EB, Beyer EV. Gippokamp i narusheniya poznavatel'noy deyatel'nosti [Hippocampus and cognitive dysfunction]. Zhurnal nevrologii i psikhiatrii. 2007;7:72-7. (in Russian).

Baranov VS, Baranova EV. Geneticheskie aspekty stareniya [Genetic aspects of aging]. Uspekhi gerontologii. 2007;20:26-4. (in Russian).

Vast'yanov RS, Oleynik AA. Neyrotropnye effekty tsitokinov i faktorov rosta [Neurotropic effects of cytokines and growth factors]. Uspekhi fiziologicheskikh nauk. 2007;38(1):39-4. (in Russian).

Islamov RR, Rizvanov AA, Guseva DS, Kiyasov AP. Gennaya i kletochnaya terapiya neyrodegenerativnykh zabolevaniy [Gene and cell therapy of neurodegenerative diseases]. Kletochnaya transplantologiya i tkanevaya inzheneriya. 2007;11(3):29-7. (in Russian).

Mukhamed'yarov MA, Zefirov AL. Vliyanie beta-amiloidnogo peptida na funktsii vozbudimykh tkaney: fiziologicheskie i patologicheskie aspekty [Influence of beta-amyloid peptide on the functions of excitable tissues: physiological and pathological aspects]. Uspekhi fiziologicheskikh nauk. 2013;44(1):55-1. (in Russian).

Mukhamed'yarov MA, Zefirov AL. Mekhanizmy kratkovremennoy formy sinapticheskoy plastichnosti [Mechanisms of short-term form of synaptic plasticity]. Rossiyskiy fiziologicheskiy zhurnal im. I.M. Sechenova. 2004;90(8):1041-59. (in Russian).

Naumenko VG. Patogeneticheskaya terapiya oslozhneniy sakharnogo diabeta [Pathogenetic therapy of complications of diabetes mellitus]. Mezhdunarodnyy endokrinologicheskiy zhurnal. 2006;1:71-6. (in Russian).

Popova MS, Stepanichev MYu. Induktsiya kletochnogo tsikla, amiloid-beta i svobodnye radikaly v mekhanizme razvitiya svobodno-radikal'nykh protsessov v mozge [Induction of the cell cycle, amyloid-beta and free radicals in the mechanism of development of free radical processes in the brain]. Neyrokhimiya. 2008;25(3):1-9. (in Russian).

Povitsenko AF, Abramov VV, Kozlov VA. Tsitokiny i faktory neyroendokrinnoy regulyatsii [Cytokines and factors of neuroendocrine regulation]. Uspekhi fiziologicheskikh nauk. 2007;38(3):40-6. (in Russian).

Bachurin SO, Grigor'ev VV, Ivanova TA. Rol' glutamatnykh retseptorov v razvitii i lechenii bolezni Al'tsgeymera [The role of glutamate receptors in the development and treatment of Alzheimer's disease]. Symposium materials [Current state of research, diagnosis and therapy of neurodegenerative diseases (Alzheimer's, Parkinson's, etc.)]. 17-18 November 2005, Moskow. Moskow; 2005. 99-104 p. (in Russian).

Garibova TL, Voronina TA, Litvinova SA. Effekt nooglyutila na povedenie i pamyat' myshey linii SAM (Senescence-accelerated mouse) s geneticheski determinirovannym uskorennym stareniem [The effect of nooglutil on the behavior and memory of SAM mice (Senescence-accelerated mouse) with genetically determined accelerated aging]. Eksperimental'naya i klinicheskaya farmakologiya. 2007;70(4):3-6. (in Russian).

Crouch PJ, Harding SM, White AR. Mechanism of A beta mediated neurodegeneretion in Alzheimers disease. Internat J Biochemistry @ Cell Biol. 2008;40(2):181-98.

Conde JR, Streit WJ. Microglia in the aging brain. Neuropathol Exp Neurol. 2006;65:199-3.

Devi L, Prabhu BM, Galati DF. Accumulation of amyloid precursor protein in the mitochondrial import channels of human Alzheimer's disease brain is associated with mitochondrial dysfunction. J Neurosci. 2006;26:905.

Gouras GK, Tampellini D, Takahashi RH, Capetillo-Zarate E. Intraneuronal beta-amyloid accumulation and synapse pathology in Alzheimer's disease. Acta Neuropathol. 2010;119:523-41.

Fjell AM, Walhovd KB. Structural brain changes in aging: courses, causes and cognitive consequences. Rev Neurosci. 2010;21(3):187-21.

Foster Е. Calcium homeostasis and modulation of synaptic plasticity in the aged brain. Aging Cell. 2007;7:319-25.

Moreira RO, Campos SC, Soldera AL. Type 2 Diabetes Mellitus and Alzheimer's Disease: from physiopathology to treatment implications. Diabetes Metab Res Rev. 2013;10:1002.

Mora F, Segovia G, ArcodelA. Aging, plasticity and environmental enrichment: structural changes and neurotransmitter dynamics in several areas of the brain. Brain Res Rev. 2007;55:78-8.

Nocolls MR. The clinical and biological relationship between Type II diabetes mellitus and Alzheimer's disease. Curr Alzheimer Res. 2004;1:47-4.

Pari L, Murugan P. Influence of tetrahydrocurcumin on tail tendon collagen contents and its properties in rats with streptozotocin- nicotinamide-induced type 2 diabetes. Fundam Clin Pharmacol. 2007;21:665-71.

Priller C, Bauer T, Mitteregger G. Synapse formation and function is modulated by the amyloid precursor protein. J Neurosci. 2006;26:7212-221.

Predrag Š, Douglas NI. Insulin and insulin-like growth factor prevent brain atrophy and cognitive impairment in diabetic rats. Indian J Endocrinol Metab. 2012;16:601-10.

Robinson LE, Buchholz AC, Mazurak VC. Inflammation, obesity, and fatty acid metabolism: influence of n-3 polyunsaturated fatty acids on factors contributing to metabolic syndrome. Appl Physiol Nutr Metab. 2007;32:1008-24.

Rodríguez-Mañas L, El-Assar M, Vallejo S. Endothelial dysfunction in aged humans is related with oxidative stress and vascular inflammation. Aging Cell. 2009;8:226-38.

Reddy PH, Manczak M, Mao P. Amyloid-beta and mitochondria in aging and Alzheimer's disease: implications for synaptic damage and cognitive decline. J Alzheimers Dis. 2010;20:499-12.

Shi J, Zhang S, Tang M. Mutation Screening and Association Study of the Neprilysin Gene in Sporadic Alzheimer’s Disease in Chinese Persons. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 2005;60:301-6.

Smith DG, Cappai R, Barnham KJ. The redox chemistry of the Alzheimer’s disease amyloid beta peptide. Biochim Biophys Acta. 2007;1768:1976-990.

Rutten BP, Korr H, Steinbusch HW, Schmitz CH. The aging brain: less neurons could be better. Mechanisms of Ageing and Development. 2003;124:349-55.


Пристатейна бібліографія ГОСТ






Copyright (c) 2019 I. R. Tymofiychuk, V. V. Gordienko, V. I. Shvets

Технічний редактор журналу, к.мед.н. М. Степанченко, 2015-2019