Роль системи матриксних металопротеїназ та їх тканинних інгібіторів у формуванні постінфарктного ремоделювання серця (аналітичний огляд літератури)

Автор(и)

  • V. K. Grin
  • O. I. Bassov
  • N. T. Vatutin
  • A. S. Vorobyov

DOI:

https://doi.org/10.24061/217861

Ключові слова:

матриксні металопротеїнази, тканинні інгібітори металопротеїназ, інфаркт міокарда, ремоделювання серця

Анотація

У даному огляді викладені сучасні уявлення про структуру та функції системи матриксних металопротеїназ (matrix metalloproteinases, MMP) та їх тканинних інгібіторів (tissue inhibitors of MMP, TIMP), а також її внесок у розвиток постінфарктного ремоделювання серця. На основі даних експериментальних та клінічних досліджень обговорюються можливості використання сироваткових рівнів MMP й TIMP в алгоритмах прогнозування віддалених постінфарктних наслідків, а також у програмах лікування ішемічної хвороби серця у постінфарктному періоді.

Посилання

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2012-05-24

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